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© 1981 Oxford University Press

research-article

Ocular Toxicity of 2,2,2-Trifluoroethanol in Rabbits

THOMAS C. MARSHALL, FLETCHER F. HAHN, BARBARA S. MERICKEL and CHARLES H. HOBBS

Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute P.O. Box 5890, Albuquerque, New Mexico 87185

Ocular Toxicity of 2,2,2-Trifluoroethanol in Rabbits. Marshall, Thomas C, Hahn, Fletcher F., Merickel, Barbara S. and Hobbs, Charles H. (1981). Fundam. Appl. Toxicol. 1:313–318. Three commercial formulations of 2,2,2-trifluoro-ethanol (TFE) were applied to eyes of rabbits and evaluated for their potential to cause ocular damage. All three products were severe eye irritants and water irrigation shortly after exposure was not effective in reducing ocular damage. Gross and histological observations revealed marked conjunctivitis, moderate to severe ulcerative keratitis, and hyperemia and edema of the iris, all of which showed evidence of resolution over the three-week course of investigation. However, complete reversal of all effects was not attained. TFE and its commercial formulations should be viewed as potentially severe human ocular irritants.


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