Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by TENNANT, B.C.
Right arrow Articles by KALLFELZ, F.A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by TENNANT, B.C.
Right arrow Articles by KALLFELZ, F.A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1981 Oxford University Press

research-article

Assessment of Hepatic Function in Rabbits with Steroid-Induced Cholestatic Liver Injury1

B.C. TENNANTA, T. BALAZSC, B.H. BALDWINA, W.E. HORNBUCKLEA, W.L. CASTLEMANB, U. BOELSTERLIC and F.A. KALLFELZA

ADepartment of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University Ithaca, NY 14853 BDepartment of Pathology, New York State College of Veterinary Medicine, Cornell University Ithaca, NY 14853 CDrug Toxicology Branch, Bureau of Drugs, Food and Drug Administration Washington, DC 20204

Assessment of Hepatic Function in Rabbits with Steroid-Induced Cholestatic Liver Injury. Tennant, B.C., Balazs, T., Baldwin, B.H., Hornbuckle, W.E., Castleman, W.L., Boelsterli, U. and Kallfelz, F.A. (1981). Fundam. Appl. Toxicol. 1:329–333. Methyltestosterone (MT) or ethinyl estradiol (EE) was administered to adult rabbits for 20 weeks beginning with initial daily doses of 0.4 mg/kg MT and 0.015 mg/kg EE for three weeks, then these dosages were doubled at 3-week intervals to a maximum dosage of 6.4 mg/kg and 0.24 mg/kg, respectively. Within 2 weeks, the serum {gamma}-glutamyltransferase activity of MT and EE treated rabbits was significantly greater than controls and increased progressively throughout the treatment period. Aspartate aminotransferase activity was also increased at 2 weeks and remained so for 17 weeks. Serum alkaline phosphatase was elevated at 2 weeks but thereafter was normal indicating that this enzyme is of no value in detecting steroid-induced hepatic dysfunction. Elevated serum bile acid concentration and prolonged BSP clearance indicated marked hepatic excretory dysfunction at higher dose levels. Histologic abnormalities were observed in the livers of both MT and EE treated rabbits. These lesions were more severe in the EE group in which there was marked bile duct proliferation, mononuclear cell infiltration of portal areas, and perilobular fibrosis. The studies indicate that the rabbit is susceptible to development of hepatic injury when receiving 17{alpha}-alkyl substituted steroids and may be a useful animal model for investigations of the pathogenesis of steroid-induced cholestatic liver injury.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.