© 1981 Oxford University Press
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Lack of Protection by Ascorbic Acid from Lethality Resulting from Exposure to 1 atm O2
Department of Pharmacology and Toxicology, Center for Environmental Toxicology, Michigan State University East Lansing, MI 48824
Lack of Protection by Ascorbic Acid from Lethality Resulting from Exposure to 1 atm O2. Roth, R.A. and Dotzlaf, L.A. (1981). Fundam. Appl. Toxicol. 1:386–388. The role of ascorbic acid in protecting animals against the toxic effects of exposure to 1 atm. of O2 was examined. The mean time until death resulting from exposure to one atm. O2 was not different in rats treated intraperitoneally 3 times per day with 1.5 g/kg ascorbic acid compared to saline injected controls. Exposure of rats to one atm. O2 for 48 hr did not alter ascorbic acid or non-protein thiol concentration in lung or liver compared to room air controls. Lung ascorbic acid concentration was markedly depressed in guinea pigs fed an ascorbic acid-deficient diet for 6 days prior to O2 exposure. However, the mean time until death of ascorbic acid-deficient guinea pigs did not significantly differ from those fed an ascorbic acid-supplemented diet. Exposure to one atm. O2 of guinea pigs fed an ascorbic acid-deficient diet or an ascorbic acid-supplemented diet failed to decrease the concentration of ascorbic acid or of non-protein thiol in lung. Results from this study do not support an involvement of ascorbic acid in protection from pulmonary oxygen toxicity.