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© 1981 Oxford University Press

research-article

Absence of Mutagenic Activity of Trifluoroethanol and its Metabolites in Salmonella Typhimurium

DAVID A. BLAKE, MARIA C. DiBLASI and GARY B. GORDON

Departments of Gynecology/Obstetrics and Pharmacology The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Absence of Mutagenic Activity of Trifluoroethanol and its Metabolites in Salmonella Typhimurium. David A. Blake, Maria C. DiBlasi and Gary B. Gordon. (1981). Fundam. Appl. Toxicol. 1:415–418. Trifluoroethanol, trifluoroacetaldehyde and trifluoroacetate were found to have no mutagenic activity in the standard Salmonella typhimurium reverse mutation assay (Ames test) using a closed incubation system. Negative results were also obtained when incubation mixtures included 9000 x g supernatant fractions of rat liver or testes homogenates along with an NADPH generating system. Rats were pretreated with a polychlorinated biphenyl mixture to induce biotransforming enzyme activity. These results suggest that the previously reported mutagenic activity of fluroxene is not due to metabolites arising from the trifluoroethyl side of the molecule and that inhibition of spermatogenesis in rats by trifluoroethanol is not mediated through a mutagenic mechanism.


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