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© 1981 Oxford University Press

research-article

Six Month Inhalation Studies of Pirbuterol Acetate Aerosol in the Beagle Dog and Squirrel Monkey

H.V. LEVINSKYA, C. BRECKENRIDGEB, R. LOUGHB, D.A. GONCIA, H.M. McILHENNYA and S. QURESHIB

ADepartment of Drug Safety Evaluation, Pfizer Central Research Eastern Point Road, Groton, Connecticut 06340 BDepartment of Inhalation Toxicology, Bio-Research Laboratories Senneville, Quebec, Canada

Six Month Inhalation Studies of Pirbuterol Acetate Aerosol in the Beagle Dog and Squirrel Monkey. Levinsky, H. V., Breckenridge, C, Lough, R., Gonci, D.A., McIlhenny, H.M. and Qureshi, S. (1981). Fundam. Appl. Toxicol. 1:426–431. Groups of Beagle dogs and Squirrel monkeys were exposed to aerosols of pirbuterol acetate, a new bronchodilator at doses of 0, 200, 400 and 800 /g of pirbuterol/kg body weight daily for 6 months. Each group consisted of 4 dogs or 6 monkeys per sex. Dogs were exposed by face mask and monkeys were exposed by head only in a manifold. Plasma drug concentrations indicated that expected levels of drug exposure were achieved in both species. No significant alterations were revealed in physical appearance and body weights, hematological and blood biochemical analyses, urinalyses, ophthalmoscopy, assessment of cardiovascular status, pulmonary function or gross and histopathology. Examination of the respiratory tract showed no morphological changes that could be attributed to pirbuterol acetate inhalation.


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