Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by LINNETT, S. L.
Right arrow Articles by CASSIDY, S. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by LINNETT, S. L.
Right arrow Articles by CASSIDY, S. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 Oxford University Press

research-article

Effects of Subchronic Inhalation of D-D (1,3-Dichloropropene/1,2-Dichloropropane) on Reproduction in Male and Female Rats1

S. L. LINNETT, D. G. CLARK, D. BLAIR and S. L. CASSIDY*

Shell Research Limited, Sitlmgbourne Research Centre, Siltingbourne Kent ME98AG, England *New Cross Hospital, Poisons Unit A vonly Road, London SEJ 45ER, England

Received February 26, 1987; accepted August 27, 1987

Effects of Subchronic Inhalation of D-D (1,3-Dichloropropene/l ,2-Dichloropropane) on Reproduction in Male and Female Rats. LINNETT, S. L., CLARK, D. G., BLAIR, D., AND CASSIDY, S. L. (1988). Fundam. Appl. Toxicol. 10, 214-223. The effects of inhaled D-D (1,3-dichloropro-pene/1,2-dichloropropane) on reproduction were studied in rats of both sexes. The rats inhaled nominal concentrations of 0, 10, 30, or 90 ppm (v/v) D-D for 6 hr/day, 5 days/week for 10 weeks. Treated males of proven fertility were paired with untreated virgin females at intervals during and after exposure. Treated females were paired with untreated males immediately after the 10-week exposure period. Various aspects of reproductive performance and general toxicity were assessed. Exposure to D-D produced no adverse effects on the libido, fertility, or morphology of the reproductive tracts of rats of either sex; no treatment-related dominant lethal effect was observed in male rats. Slight reductions in body weight gains and slight increases in liver and kidney weights were observed in 90 ppm rats of both sexes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.