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© 1988 Oxford University Press

research-article

An Evaluation of the Genotoxic Potential of Glyphosate1

A. P. LI2 and T. J. LONG

Monsanto Company 800N. Lindbergh Boulevard, St. Louis. Missouri 63167

Received August 13, 1987; accepted November 10, 1987

An Evaluation of the Genotoxic Potential of Glyphosate. Li, A. P., AND LONG, T. J. (1988). Fundam. Appl. Toxicol. 10, 537–546. The potential genotoxicity of glyphosate, the active ingredient in Roundup herbicide, was tested in a vanety of well-established in vitro and in vivo assays including the Salmonella lyphimurium and Eschenchia coli WP-2 reversion assays, recombination (rec-assay) with Bacillus subtilis, Chinese hamster ovary cell gene mutation assay at the hypoxanthine/guanine phosphoribosyl transferase gene locus, hepatocyte primary culture/ DNA repair assay, and in vivo cytogenetics assay in rat bone marrow. No genotoxic activity was observed in the assays performed. The data suggest that glyphosate should not pose a genetic risk to man.


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