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© 1988 Oxford University Press

research-article

Mathematical and Biostatistical Methods for Designing and Analyzing Complex Interactions1

W. H. CARTER, JR* and R. A. CARCHMAN{dagger}

*Department of Biostatistics, Medical College of Virginia, Virginia Commonwelath University Richmond, Virginia 23298-0001 {dagger}Department of Pharmacology and Toxicology, Medical College of Virginia Virginia Commonwealth University Richmond, Virginia 23298-0001

Received November 6, 1987; accepted November 18, 1987

Mathematical and Biostatistical Methods for Designing and Analyzing Complex Chemical Interactions. CARTER, W.H., Jr., AND CARCHMAN, R.A. (1988). Fundam Appl. Toxicol 10, 590–595. In this presentation, statistical methods for designing and analyzing experiments evaluating a mixture of drugs/chemicals are discussed. These methods are promising in that they are not limited by the number of interacting agents in the combination. Several examples are given and a discussion of the results follows.


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