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© 1988 Oxford University Press

research-article

Decrease of Serum Triglyceride in Normal Rats Fed with 2000 ppm Aluminum Diet for 67 Days

Feeding Young Rats Sucrose, Lactose, Milk, Casein or Soy-Protein Diets with Addition of Aluminum Chloride1

C. SUGAWARA, N. SUGAWARA, H. KIYOSAWA and H. MIYAKE

Department of Public Health, Sapporo Medical College S-1, W-17, Sapporo, 060 Japan

Received April 29, 1987; accepted January 18, 1988

Decrease of Serum Triglyceride in Normal Rat Fed with 2000 ppm Aluminum Diet for 67 Days. II. Feeding Young and Adult Rats a Sucrose Diet with Addition of Aluminum Hydroxide and Aluminum Potassium Sulfate. SUGAWARA, C, SUGAWARA, N., KJYOSAWA, H., AND MIY-AKE, H. (1988) Fundam. Appl Toxicol 10, 616–623. To confirm the hypotriglycendemic effect of aluminum (AI), male weanling and adult Wistar rats were fed sucrose diets with the addition of aluminum hydroxide (A1(OH)3) or aluminum potassium sulfate (A1K(SO4)2) for 67 days. As in the foregoing report (C. Sugawara, N. Sugawara, H. Kjyosawa, and H. Miyake, Fundam. Appl Toxicol. 10, 607–615), no Al-induced anemia or hypophosphatemia was observed and serum AI did not exceed 20 ng/ml. Serum tnglyceride (TG) was decreased by aluminum. Serum TG was significantly correlated with the serum nonesterified fatty acid (NEFA) concentration in both the Young groups (R = 0.757, n = 22, p < 0.01) and the Adult groups (R = 0.727, n = 19, p < 0.01). Neither serum cholesterol nor phospholipids was affected by AI ingestion. Aluminum caused a decrease in hepatic glycogen in all groups, but the decrease was significant only in Adult groups. Glycerol tn[9,10(n)-3H]oleate was administered by gastric tube into rats fed for 81 days with experimental diets. In all the Al-treated groups serum 3H was significantly greater than in control groups at 3 hr after intubation. At 24 hr after intubation, serum 3H did not differ between Control and Al-treated groups. Total 3H at 24 hr found in serum, liver, and epididymal adipose tissue was not changed significantly by AI feeding. These effects were observed without measurable increase of AI in the serum. The aorta TG concentration was decreased slightly by AI treatment. Whether an Al-dependent hypotriglycendemic effect occurs in human beings and what other effects, if any, AI has on man should be investigated in the future.


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