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© 1988 Oxford University Press

research-article

Teratology Studies of Compound Lyn 171883 Administered Orally to Rats and Rabbits

GEORGE S. HAGOPIAN1, DENNIS M. HOOVER and JANET K. MARKHAM2

Lilly Research Laboratories, Toxicology Division P.O. Box 708, Greenfield, Indiana 46140

Received July 6, 1987; accepted December 21, 1987

Teratology Studies of Compound LY171883 Administered Orally to Rats and Rabbits. HA-GOPIAN, G. S., HOOVER, D. M., AND MARKHAM, J. K. (1988). Fundam Appl Toxicol. 10, 672–681. The teratogenic potential of the leukotriene antagonist LY171883, a novel antiasthma agent, was investigated in CD rats and Dutch Belted rabbits. Mated female rats were dosed with 0, 10, 65, or 425 mg/kg/day on gestation days 6 through 15 and killed on gestation day 20. Mated female rabbits were dosed with 0, 20, 65, or 200 mg/kg/day on gestation days 6 through 18 and killed on gestation day 28. Maternal toxicity was indicated at 425 mg/kg in rats and 200 mg/kg in rabbits by depressed body weight gain and food consumption. In the rabbit study four abortions occurred at 200 mg/kg, most likely secondarily to maternal toxicity. LY171883 did not cause embryo/fetal toxicity or teratogenicity in rats or rabbits at doses up to and including those that were maternally toxic.


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