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ToxSci Advance Access originally published online on June 19, 2008
Toxicological Sciences 2008 106(1):5-28; doi:10.1093/toxsci/kfn121
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

Maxwell C. K. Leung*, Phillip L. Williams{dagger}, Alexandre Benedetto{ddagger}, Catherine Au{ddagger}, Kirsten J. Helmcke{ddagger}, Michael Aschner{ddagger} and Joel N. Meyer*,1

* Nicholas School of the Environment, Duke University, Durham, North Carolina 27750 {dagger} Department of Environmental Health Science, College of Public University of Georgia, Athens, Georgia 30602 {ddagger} Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37240

1 To whom correspondence should be addressed at Nicholas School of the Environment, Box 90328, Duke University, Durham, NC 27708-0328. Fax: (919) 668-1799. E-mail: joel.meyer{at}duke.edu.

Received April 30, 2008; accepted June 10, 2008


  Abstract

The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of maintenance, short and prolific life cycle, and small body size. These same features have led to an increasing use of C. elegans in toxicology, both for mechanistic studies and high-throughput screening approaches. We describe some of the research that has been carried out in the areas of neurotoxicology, genetic toxicology, and environmental toxicology, as well as high-throughput experiments with C. elegans including genome-wide screening for molecular targets of toxicity and rapid toxicity assessment for new chemicals. We argue for an increased role for C. elegans in complementing other model systems in toxicological research.

Key Words: Caenorhabditis elegans; neurotoxicity; genotoxicity; environmental toxicology; high-throughput methods.


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