Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by KATO, M.
Right arrow Articles by ONODERA, T.
Right arrow Search for Related Content
PubMed
Right arrow Articles by KATO, M.
Right arrow Articles by ONODERA, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 Oxford University Press

research-article

Morphological Investigation of Cavity Formation in Articular Cartilage Induced by Oiloxacin in Rats

MICHIYUKI KATO and TAKESHI ONODERA

Drug Safety Research Centre, Research Institute, Dauchi Sertajy Co. Ltd Tokyo Japan

Received August 11, 1987; accepted January 25, 1988

Morphological Investigation of Cavity Formation in Articular Cartilage Induced by Ofloxacin in Rats. Kato, M., andOnodera, T.( 1988).Fundam. Appl Toxwol. 11, 110–119. Ofloxacin, a quinolone antibacterial agent, induced blisters and/or erosions in the articular cartilage of the humeral trochlea, femoral condyle, and femoral head of immature rats. Histologically, cavity formation was seen in the middle zone of the articular cartilage. Changes were detected as early as 5 hr after a single oral administration of 1000 or 3000 mg/kg. These changes were characterized by condensation, atrophy, and deformation of the nuclei of chondrocytes distributed in the middle zone. In such nuclei, aggregation of heterochromatin was observed. Degenerated cells with vacuolated and partially disintegrated cytoplasms were also seen in this zone. These lesions were followed by edema of the matrix accompanied with markedly decreased stainability with safranin-O, and a cavity was formed later by liquefaction of the cartilage. The changes were reversible, with rebounding occurring even with continued treatment with ofloxacin. The proliferation of chondrocytes around the lesion chiefly contributed to the repair. Ofloxacin had no adverse effects on the articular cartilage in rats when treatment was initiated at 8 weeks of age or later.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.