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© 1988 Oxford University Press

research-article

Mercapturic Acid Excretion by Rats following Inhalation Exposure to m1,3-Dichloropropene1

GREGORY D. FISHER and WENDELL W. KILGORE

Department of Environmental Toxicology, University of Califormia Davis, California 95616

Received December 8, 1986; accepted January 29, 1988

Mercapturic Acid Excretion by Rats following Acute Inhalation Exposure to 1,3-Dichloro-propcne. Fisher, G. D., and Kjlgore, W. W. (1988). Fundam Appl. Toxicol. 11, 300–307. Rats were exposed to 1,3-dichloropropene (DCP), a commonly used agricultural nematicide, by inhalation to assess the relationship between DCP concentration and the urinary excretion of the mercapturic acid of cis-DCP (3C-NAC). The nose-only exposure system that was used for simultaneously exposing up to four rodents is described. This apparatus provided for generation and monitoring of relative humidity and test vapor concentration. Animals were exposed for 1 hr to concentrations of up to 789 ppm DCP. Urine was collected for 24 hr after exposure. The quantity of 3C-NAC contained in the urine collections exhibited an exposure concentration-dependent increase from 0 to 284 ppm DCP. However, the amount of 3C-NAC was no greater for animals exposed to 398 or 789 ppm DCP than for animals exposed to 284 ppm DCP. C 1988 Society of Toxicology


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