Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by YOUNG, S. S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by YOUNG, S. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 Oxford University Press

meeting-report

A Blind Reanalysis of a Random Subset of NCI Bioassay Studies: Agreement between Rats and Mice

Introduction to Symposium

S. STANLEY YOUNG

Statistical Services, Glaxo Inc. 5 Moore Drive, Research Triangle Park, North Carolina 27709

Received July 15, 1988; revision received August 10, 1988; Three groups of statisticians were asked to reanalyze a random subset of 25 companion rat and mouse NCI bioassay studies. Initially, the correspondence between rat and mouse studies was not given. After each group devised decision rules for declaring carcinogenicity, applied the rules, and reported the results, the correspondence was disclosed. Three complicated and different decision rules were devised. These decision rules differed extensively not only in their mathematical detail, but also in their biological end points. Each appeared reasonable, but they produced very different results. For example, the probability of a compound being declared positive ranged from 31 to 96%. Previously, the NCI had declared 46% of the studies positive. Many features of the analysis of long-term studies are explored in the three accompanying papers.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.