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© 1989 Oxford University Press

research-article

Effects of Hepatic Inducers on Testicular Epoxide-Metabolizing Enzymes in the Rat and Mouse1

KAREN W DIBIASIO*, MARILYN H SILVA{dagger},2, BRUCE D HAMMOCK*,{dagger} and LEE R SHULL*,3

*Department of Environmental Toxicology University of California, Davis, California 95616 {dagger}Department of Entomology, University of California Davis, California 95616

Received March 24, 1988; accepted August 8, 1988

Effects of Hepatic Inducers on Testicular Epoxide-Metabolizing Enzymes in the Rat and Mouse. DIBIASIO, K. W., SILVA, M. H., HAMMOCK B. D., AND SHULL, L. R. (1989). Fundam. Appl. Toxicol. 12, 449–459. Testicular toxicants have become of increasing importance, necessitating a better understanding of the possible role of testicular xenobiotic metabolism. The responsiveness of testicular microsomal epoxide hydrolase (mEH), cytosolic epoxide hydrolase (cEH), and cytosolic glutathione S-transferase (cGST to hepatic inducers was studied in sexually mature male F344 rats and CD-1 mice. The hepatic inducers employed were phenobarbital (PB), ß-naphthoflavone (BNF), and butylated hydcoxyanisole (BHA) which are known to induce cytochrome P-450, cytochrome P-448, and cGST, respectively. Hepatic mEH, cEH, and cGST activities were assessed as positive controls. Measurable activities of all enzymes studied were present in the testes of both rats and mice. PB, BNF, and BHA produced the expected effects on mEH, cEH, and cGST in rat and mouse livers, whereas the testes were generally nonresponsive to the inducers. Induction of testicular cGST by PB occurred in mice but not rats and was the only testicular effect produced by the hepatic inducers in this study.


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