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© 1989 Oxford University Press

research-article

The Effects of Inhalation Exposure to Sulfuryl Fluoride on Fetal Development in Rats and Rabbits

T. R. HANLEY, JR.1, L. L. CALHOUN, R. J. KOCIBA and J. A. GREENE2

Mammalian and Environmental Toxicology Research Laboratory, Health and Environmental Sciences Dow Chemical Company, Midland, Michigan 48674

Received May 2, 1988; accepted August 19, 1988

Sulfuryl fluoride is a fumigant insecticide used for soils and permanent structures. Pregnant Fischer 344 rats and New Zealand White rabbits were exposed to 0, 25, 75, or 225 ppm of sulfuryl fluoride vapor via inhalation for 6 hr/day on Days 6–15 and 6–18 of gestation, respectively. Among rats, maternal water consumption was increased in the 225 ppm exposure group, but there were no indications of embryotoxicity, fetotoxicity, or tera-togenicity in any of the exposed groups. Among rabbits, maternal weight loss during the exposure period (Days 6–18) was observed in the 225 ppm group. Decreased fetal body weights, considered secondary to maternal weight loss, were also observed at 225 ppm. However, no evidence of embryotoxicity or teratogenicity was observed among rabbits in any exposure group. Thus, inhalation exposure to sulfuryl fluoride was not teratogenic in either rats or rabbits exposed to levels of up to 225 ppm, and fetotoxic effects (reduced body weights) were observed among fetal rabbits only at an exposure level that produced maternal weight loss.


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