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© 1989 Oxford University Press

research-article

Reproductive Toxicity of 2,2-Bis(bromomethyl)-1,3-propanediol in a Continuous Breeding Protocol in Swiss (CD-1) Mice

KIMBERLEY A. TREINEN, ROBERT E. CHAPIN, DUSHYANT K. GULATI*, ROBIN MOUNCE*, LISA Z. MORRIS* and JAMES C. LAMB, IV{dagger}

National Institute of Environmental Health Sciences, National Toxicology Program P.O Box 12233, Research Triangle Park, North Carolina 27709 *Environmental Health Research and Testing, Inc. 2514 Regency Road, Lexington, Kentucky 40503 {dagger}Jellinek, Schwartz, Connolly, and Freshman, Inc. 1015 15th St. NW, Suite 500, Washington, DC 20005

Received June 20, 1988; accepted February 15, 1989

The effect of 2,2-bis(bromomethyl)-1,3-propanediol (BMP) on reproduction in Swiss CD-1 mice was evaluated by use of a continuous breeding protocol. BMP was administered in the feed at 0.1, 0.2, and 0.4% concentrations. Both male and female F0 mice (20 pairs per treatment group, 40 pairs of control animals) were dosed 7 days prior to and during a 98-day cohabitation period. Although the fertility index was unchanged in the highdose group, BMP exposure significantly decrased the numbers of litters per pair, pups born alive per litter, and pup weight when adjusted for litter size. Crossover mating between treated and control F0 animals indicated a specific effect only on female reproductive capacity. At the highest dose, BMP caused a body weight decrease in the F0 animals of both sexes with no effect on relative organ weights. Sperm concentration, motility, morphology, and estrual cyclicity were unaffected by BMP exposure. Histopathology in the F0 animals revealed specific kidney lesions in both sexes; males were more sensitive than females. The last litter born in the 98-day breeding phase was reared to age 74 days and then mated to nonsiblings of the same treatment group. The effect of highdose BMP exposure on F1, fertility, body and organ weights, sperm parametem, and estrual cyclicity was the same as that for the F0 animals, with the exception of the lack of renal lesions seen in the F1, females. These data show that BMP impaired fertility in female mice in both generations in the absence of an effect on reproductive organ weights and estrual cyclicity.


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