Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by WADDELL, W. J.
Right arrow Articles by FRIEDMAN, M. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by WADDELL, W. J.
Right arrow Articles by FRIEDMAN, M. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

other

The Distribution of [14C]Acrylamide in Rainbow Trout Studied by Whole-Body Autoradiography1,2

WILLIAM J. WADDELL*,3, JOHN J. LECH{dagger}, CAROLYN MARLOWE*, KEVIN M. KLEINOW{dagger} and MARVIN A. FRIEDMAN*,{ddagger}

*Department of Pharmacology and Toxicology, University of Louisville Louisville, Kentucky 40292; {dagger}Department of Pharmacology and Toxicology, Medical College of Wisconsin Milwaukee, Wisconsin 53226 {ddagger}American Cyanamid Company Wayne, New Jersey 07470

Received January 16, 1989; accepted June 27, 1989

The Distribution of [14C]Acrylamide in Rainbow Trout Studied by Whole-Body Autoradiog-raphy. WADDELL, W. J., LECH, J. J., MARLOWE, C, KLEINOW, K. M., AND FRIEDMAN, M. A. (1990). Fundam. Appl. Toxicol. 14, 84–87. The distribution of [2,3-14CJacrylamide was studied in fingerling rainbow trout by whole-body autoradiography. Fish weighing approximately 7 g were injected ip with 3.2 mg/kg [14CJacrylamide (0.1 µCi/g). One group offish was kept in a fresh flowing water tank and frozen in dry ice/hexane 22 hr after injection; another group was placed in a separate tank of fresh flowing water and frozen 120 hr after treatment A third group offish served as nontreated controls. The autoradiographs of the fish at 22 hr show the highest concentration of radioactivity in the kidney, urinary bladder, blood, gallbladder, intestinal contents, and lens of eye. Lesser amounts of radioactivity are seen in the CNS, liver, and gills. Very low concentrations are seen in muscle. By 120 hr the only high concentrations are seen in gallbladder and lens of the eye. Lesser amounts are seen in the sclera, vertebrae, CNS, kidney, wall of intestine, and discrete spots in subcutaneous tissue presumed to be chromatophores. Low amounts are seen in muscle, the tissue usually consumed by man.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.