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© 1990 Oxford University Press

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The Modulation of Gap Junctional Communication by Gossypol in Various Mammalian Cell Lines in vitro1

YI-XIN YE*,{dagger}, DAVID BOMBICK{dagger},{ddagger}, KENDALYN HIRST{dagger},{ddagger}, GUIXIANG ZHANG*,{dagger}, CHIA-CHENG CHANG{dagger},{ddagger}, JAMES E. TROSKO{dagger},{ddagger},2 and TAI AKERA*,{dagger}

*Departments of Pharmacology and Toxicology, Michigan Stale University East Lansing, Michigan 48824 {ddagger}Departments of Pediatrics/Human Development, Michigan Stale University East Lansing, Michigan 48824 {dagger}Departments of Centerfor Environmental Toxicology, Michigan Stale University East Lansing, Michigan 48824

Received September 18, 1989; accepted November 8, 1989

The Modulation of Gap Junctional Communication by Gossypol in Various Mammalian Cell Lines in vitro YE, Y.-X., BOMBICK, D., HIRST, K., ZHANG, G., CHANG, C. C, TROSKO, J. E., AND AKERA, T. (1990). Fundam. Appl. Toxicol. 14, 817–832. The effects of gossypol were examined in several cell lines including hamster V79 lung fibroblasts, WB-344 rat liver oval cells, human osteosarcoma cells and LC540 rat Leydig cells. Gossypol had little cytotoxic effects in these cell lines except at high concentrations. Plasma membrane integrity was maintained in LC54O except at high concentrations of gossypol. Gossypol did not increase mutational frequency as examined by the hypoxanthine guanine phosphoribosyl transferase and Na+,K+-ATPase loci in V79 cells. Gossypol inhibited gap junctional intercellular communication in some but not all of the cell lines. This selectivity might be the basis for the sensitivity of certain tissues or organs to gossypol. For example, the Leydig cell, which is the component of a target organ system for toxicity, was sensitive to gossypol. Modulation of gap junctional functions might play a significant role in both pharmacological and toxicological effects of gossypol.


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