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© 1990 Oxford University Press

research-article

Modulation of Pulmonary Eicosanoid Metabolism following Exposure to Sulfuric Acid

RICHARD B. SCHLESINGER, ALBERT F. GUNNISON and JUDITH T. ZELIKOFF

Institute of Environmental Medicine, New York University Medical Center 550 First Avenue, New York, New York 10016

Received November 17, 1989; accepted February 8, 1990

Modulation of Pulmonary Eicosanoid Metabolism following Exposure to Sulfuric Acid. SCHLESINGER, R. B., GUNNISON, A. F., AND ZELIKOFF, J. T. (1990). Fundam. Appl. Toxicol. 15, 151–162. Eicosanoids (arachidonic acid metabolites) are potent biological mediators. Modulation of their metabolism by air pollutants may be a possible factor in the pathogenesis of environmentally related lung disease. Sulfuric acid (H2SO4) aerosols are components of ambient air in many areas. Rabbits were exposed to H2SO4 (0.3 µm) at 250, 500, or 1000 µg/m3 for 1 hr/ day for 5 days. They were then euthanized, the lungs lavaged, and eicosanoid analyses performed by radioimmunoassay of acellular lavage fluid. An exposure-concentration-dependent decrease in levels of prostaglandins E2 and F2{alpha} and thromboxane B2 was found; no change in leukotriene B4 was observed. Tracheal explants exposed to acidic environments in vitro also showed reduced production of PGE2, PGF2{alpha}, and TxB2. Incubation with sodium sulfate (Na2SO4 showed no effect of the sulfate ion (SO42–). This study, the first to examine eicosanoid production after in vivo exposure to pure H2SO4 droplets, indicates that such exposure can modulate arachidonic acid metabolism, and that this is likely due to the deposition of hydrogen ion (H+ on target issue.


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