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© 1990 Oxford University Press

research-article

Toxic Interactions of the Munitions Compounds TNT and RDX in F344 Rats1,2

B. S. LEVINE*, E. M. FUREDI{dagger}, D. E. GORDON{ddagger}, J. J. BARKLEY§ and P. M. LISH{dagger}

*Department of Pharmacology, University of Illinois at Chicago Box 6998, Chicago, Illinois 60680 {dagger}Life Sciences Department IIT Research Institute, Chicago, Illinois 60616 {ddagger} Highland Park, Illinois 60635 §U.S. Army Bioengineering and Development Laboratory Fort Detrick, Frederick, Maryland 27101

Received September 5, 1989; accepted April 26, 1990

Toxic Interactions of the Munitions Compounds TNT and RDX in F344 Rats. LEVINE, B. S., FUREDI, E. M., GORDON, D. E., BARKLEY, J. J., AND LISH, P. M. (1990). Fundam. Appl. Toxi-col. 15, 373–380. The potential toxic interactions in F344 rats of the munitions compounds trinitrotoluene (TNT) and hexahydro-l,3,5-trinitro-l,3,5-triazine (RDX) were examined following their coadministration in the diet. Groups of 10 rats per sex received TNT at doses of 5 or 125 mg/kg/day, RDX at doses of 30, 100, or 300 mg/kg/day, and combinations thereof for 13 weeks. Thirty rats per sex served as controls. Toxicologic endpoints included clinical observations, body weight, food consumption, hematology, clinical chemistry, organ weights, and tissue morphology. The major toxic effects following the dietary administration of TNT to rats included anemia, hypercholesterolemia, and hepatomegaly, splenomegaly, and testicular atrophy with their accompanying histologic lesions. RDX intoxication in rats included hypotri-glyceridemia, behavioral changes, and mortality. Most of the toxic effects of these chemicals were partially antagonized following their coadministration


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