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© 1990 Oxford University Press

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Increased Hyaline Droplet Formation in Male Rats Exposed to Decalin Is Dependent on the Presence of {alpha}2u-Globulin

GREGG M. RIDDER, EDWARD C. VON BARGEN, CARL L. ALDEN and RONALD D. PARKER

The Procter & Gamble Company, Miami Valley Laboratories Cincinnati, Ohio 45239–8707

Received February 27, 1990; accepted July 6, 1990

Increased Hyaline Droplet Formation in Male Rats Exposed to Decalin Is Dependent on the Presence of {alpha}2u-Globulin. RIDDER, G. M., VON BARGEN, E. C., ALDEN, C. L., AND PARKER, R. D. (1990). Fundam. Appl. Toxicol. 15, 732–743. A peculiar decalin-induced male rat nephropathy associated with the altered renal handling of filtered protein appears limited to the accumulation of the protein, {alpha}2u-globulin. Several strains of male rats that produce {alpha}2u-globulin (Fischer-344, Sprague-Dawley, Buffalo, and Norway Brown) demonstrate spontaneous renal cortical hyaline droplets which are exacerbated after exposure to decalin. In all cases, a close correlation exists between hyaline droplet formation observed histologically and {alpha}2u-globulin accumulation measured biochemically. In stark contrast, the NCI-Black-Reiter strain, which does not produce measurable quantities of {alpha}2u-globulin, neither forms hyaline droplets nor accumulates any filtered protein in its kidney cortex either spontaneously or after exposure to decalin. Also, female rats injected ip with male rat {alpha}2u-globulin exhibit increased hyaline droplet formation and {alpha}2u-globulin accumulation when treated with decalin. These data provide evidence that the presence of {alpha}2u-globulin is key in understanding why this nephropathy appears unique to the male rat.


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