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© 1991 Oxford University Press

research-article

Tumors of the Skin in the HRA/Skh Mouse after Treatment with 8-Methoxypsoralen and UVA Radiation

JUNE K. DUNNICK*,1, P. DONALD FORBES{dagger}, SCOT L. EUSTIS*, JERRY F. HARDISTY{ddagger} and DAWN G. GOODMAN§

*National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709 {dagger}Temple University Health Sciences Center Philadelphia, Pennsylvania 19122 {ddagger}Experimental Pathology Laboratories Research Triangle Park, North Carolina 27709 §PATHCO, Inc. Gaithersburg, Maryland 20879

Received March 2, 1990; accepted September 11, 1990

8-Methoxypsoralen (8-MOP) with and without UVA radiation was administered to HRA/Skh mice (36 animals per treatment group) three times a week in the feed for a total dose of 9–80 mg/kg/week for 52 weeks. Most of the animals at the top dose of 8-MOP with UVA radiation had developed skin toxicity and/or skin tumors by 52 weeks. The skin lesions seen after treatment with 8-MOP and UVA radiation were characterized as squamous cell hyperplasia, squamous cell papilloma, and squamous cell carcinoma and are similar to what has been reported in humans after exposure to 8-MOP and UVA. Squamous cell hyperplasia and acute inflammation of the cornea were also seen in some of the treated female mice. Oral administration of 8-MOP and UVA did not result in a carcinogenic response to other organ systems. There were no increases in skin neoplasms after 8-MOP or UVA radiation alone. 8-MOP given in combination with UVA was carcinogenic to the skin of mice at dose levels similar to those used to treat psoriasis in humans.


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