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© 1991 Oxford University Press

research-article

Difference in the Developmental Toxicity of Ethylenethiourea and Three N,N'-Substituted Thiourea Derivatives in Rats

A. M. SAILLENFAIT, J. P. SABATE, I. LANGONNE and J. DE CEAURRIZ

Institut Ndional de Recherche et de Sécurité 54501 Vandoeuvre, France

Received October 12, 1990; accepted March 29, 1991

Difference in the Developmental Toxicity of Ethylenethiourea and Thm N,N'-Substituted Thiourea Derivatives in Rats. SAILLENFAIT, A. M., SABATE, J. P., LANGONNE, I., AND DE CUURRIG J. (1991). Fundam. Appl Toxicol 17, 399–408. Sprague-Dawley rats were administered ethylenethiourea (ETU), 1,3-dimethyl-2-thiourea (DMT), 1,3-dibutyl-2-thiourea (DBT), or 1,3-diphenyl-2-thiourea (DPT) by gavage from Days 6 to 20 of gestation. Daily dosage levels (mg/kg/day) were ETU at 0, 15, 25 and 35; DMT at 0, 15, 25, 50, 100, and 200; DBT at 0, 15,25, 50, 100, and 200; and DPT at 0,25, 50, 100, and 200. There was evidence of maternal toxlcity at all doses of DMT and at doses ≥ 50 mg DBT/kg/day. DPT was embryolethal at 200 mg/kg/day. Fetotoxicity was observed at doses ≥ 15 mg DMT/kg/day, ≥ 15 mg DBT/kg/day, and ≥ 100 mg DPT/kg/day. ETU was the only chemical tested that proved to be teratogenic.


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