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© 1992 Oxford University Press

research-article

Inhalation Toxicity of an Isomeric Mixture of Hydrochlorofluorocarbon (HCFC) 225 in Male Rats

STEVEN R. FRAME, MICHAEL C. CARAKOSTAS and DAVID B. WARHEIT

E.I. du Point de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine P.O. Box 50, Elkion Road, Newark; Delaware 19714

Received July 1, 1991; accepted November 18, 1991

A blend of the hydrochiorofluorocarbon isomers HCFC-225ca and HCFC-225cb has been proposed as a potential substitute for CFC-113, an important solvent and cleaning agent. The toxicity following repeated inhalation of an HCFC-225 isomer mixture was assessed in male Crl:CDBR rats. Three groups of 10 male rats were exposed to the test compound in air at design concentrations of 500,5000, and 13,000 ppm. Rats were exposed 6 hr/day, 5 days/week for 2 weeks. A control group of 10 male rats was exposed to air only. Decreased serum cholesterol, triglycerides, and glucose; dose-related increased mean absolute and relative liver weights; and microscopic hepatocellular hy pertrophy were present at all exposure concentrations. Hepatocellular hypertrophy correlated ultrastructurally to proliferation of peroxisomes. Clinical chemical parameters and organ weight and morphologic changes in the liver were reversible following 14 days of recovery.


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