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© 1992 Oxford University Press

research-article

Developmental Toxicity of 2,4,5-Trichiorophenoxyacetic Acid (2,4,5-T)

II. Multireplicated Dose-Response Studies with Technical and Analytical Grades of 2,4,5-T in Four-Way Outcross Mice

C. J. NELSON*, J. F. HOLSON{dagger}, T. B. GAINES{ddagger}, J. B. LABORDE§, W. F. MCCALLUM, G. L. WOLFF||, D. M. SHEEHAN§ and J. F. YOUNG§

*USEPA (MD-56), Alexander Drive, Research Triangle Park North Carolina 27711 {dagger}WIL Research Laboratories, Inc., Ashland Ohio 44805–9281 {ddagger}Number 6 Athena Court, Little Rock Arkansas 72205 §Division of Reproductive & Developmental Toxicology Jefferson, Arkansas 72079–9502 Division of Veterinary Services Jefferson, Arkansas 72079–9502 ||Division of Comparative Toxicology, National Center for Toxicological Research Food and Drug Administration, Department of Health and Human Services Jefferson, Arkansas 72079-9502

Received October 15, 1991; accepted March 6, 1992

A series of multireplicated developmental toxicity studies were conducted in four-way outcross mice and CD-1 outbred mice administered either analytical or technical grades of 2,4,5-tri-chlorophenoxyacetic acid (2,4,5-T) by gavage on Gestational Days 6 through 14. The formulations of 2,4,5-T differed by a factor of 10-fold in 2,3,7,8-tetrachlorodibenzo-p-dioxin levels. Reduced fetal weight and increased incidences of cleft palate and embryolethality were the most significant prenatal effects of both formulations of 2,4,5-T observed in all strains/stocks of mice. Both the outcross and outbred mice exhibited a dose-response relationship with each of the above endpoints and the dose-response curves were parallel. There were no embryotoxic or fetotoxic differences between the technical and analytical grades of 2,4,5-T with regard to extent of fetal weight reduction, resorption rate, or cleft palate incidence. There was little difference in the results between the four-way outcross mouse and the CD-1 outbred mouse.


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