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© 1982 Oxford University Press

research-article

Dependence of Apparent Blood Lead Half-Life on the Length of Previous Lead Exposure in Humans

E.J. O'FLAHERTY, P.B. HAMMOND and S.I. LERNER

Department of Environmental Health, University of Cincinnati Cincinnati, OH 45267

Dependence of Apparent Blood Lead Half-Life on the Length of Previous Lead Exposure in Humans. O'FIaherty, E.J., Hammond, P.B. and Lerner, S.I. (1982). Fundam. Appl. Toxicol. 2:49–54. The expected relationship between the apparent half-life of blood lead (PbB) and the length of previous exposure is compared with the observed relationship in a group of workers on strike from a primary smelter where they had been employed for from a few months to ten years. Within this group, the apparent PbB half-life was positively correlated both with pre-strike PbB and with length of exposure to lead. It is likely that the dependence of apparent half-life on pre-strike PbB is primarily a reflection of interindividual differences in lead kinetics in these men. The direct dependence of apparent half-life on duration of lead exposure is consistent with published data from former lead workers and from human subjects experimentally exposed to lead.


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