© 1982 Oxford University Press
research-article |
Mycotoxicosis Caused by Either T-2 Toxin or Diacetoxyscirpenol in the Diet of Broiler Chickens
ADepartment of Veterinary Microbiology and Pathology, School of Veterinary Medicine, Purdue University West Lafayette, IN 47907 BDepartment of Natural Products, Laboratory of Mycology and Mycotoxicology, Hebrew University Jerusalem, Israel CDepartment of Botany, Laboratory of Mycology and Mycotoxicology, Hebrew University Jerusalem, Israel
Mycotoxicosis Caused by Either T-2 Toxin or Diacetoxyscirpenol in the Diet of Broiler Chickens. Hoerr, F.J., Carlton, W.W., Yagen, B. and Joffe, A.Z. (1982). Fundam. Appl. Toxicol. 2:121-124. Seven-day-old male broiler chickens were fed either T-2 toxin or diacetoxyscirpenol at 4 and 16 ppm for 21 days and had reductions of feed consumption and of weight gain. Focal, yellow, oral plaques developed by day 2 and were located around salivary duct openings on the palate, tongue, and buccal floor. The plaques progressed to raised, yellowish-gray crusts which covered ulcers. Microscopically, the ulcers had a base of granulation tissue and inflammatory cells, and the crusts comprised exudate, bacterial colonies and feed components. T-2 toxin and diacetoxyscirpenol produced similar effects at these concentrations. Comparable lesions also occurred in chickens fed T-2 toxin at 50, 100, or 300 ppm for 7 days. Six of 10 chickens died in the 300-ppm group which received an average daily exposure of about 10 mg T-2 toxin/kg body weight. In dead chickens, the lymphoid and hematopoietic tissues and alimentary mucosa were necrotic. Necrosis was seen less frequently in the liver, kidney and the feather. Survivors of the 7-day studies had atrophied lymphoid organs and were anemic.