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© 1993 Oxford University Press

research-article

Heinz Body Hemolytic Anemia Induced by DQ-2511, a New Anti-ulcer Drug, in Dogs

HIROSHI OHNO, HIROKO TOJO, KOJI KAKIHATA, MAMORU NOMURA and SATOSHI TAKAYAMA

Drug Safety Research Center, Developmental Research Laboratories, Datichi Pharmaceutical Company Ltd. Tokyo R & D Center, 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134, Japan

Received May 11, 1992; accepted September 16, 1992

DQ-2511, a new anti-ulcer drug, was administered to beagle dogs for 4 weeks to investigate the mechanism whereby this drug induced hemolytic anemia and its reversibility in comparison with ß-acetylphenylhydrazine. Hemolytic anemia accompanied by an increase in the number of cells containing Heinz bodies that was preceded by a marked decrease in blood-reduced glutathione concentration was observed in dogs receiving 600 mg/kg of DQ-2511, but only a slight increase in the methemoglobin level was noted.ß-Acetylphenylhydrazine, however, caused hemolytic anemia accompanied by marked increases in both Heinz body-containing cells and methemoglobin concentration, but the blood-reduced glutathione concentration was not decreased consistently with the formation of Heinz bodies. Hemolytic anemia disappeared after a 4-week recovery period in the dogs that received DQ-2511. These results suggest that decreases in reduced glutathione in erythrocytes play an important role in the anemia and Heinz body formation induced by DQ-2511, but not by ß-acetylphenylhydrazine.


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