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© 1993 Oxford University Press

research-article

Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

SHERRY E. RIER*,||, DAN C. MARTIN{dagger}, ROBERT E. BOWMAN{ddagger}, W. PAUL DMOWSKI§ and JEANNE L. BECKER*,||

*Department of Medical Microbiology and Immunology, University of South Florida College of Medicine Tampa, Florida 33612 ||Department of Obstetrics and Gynecology, University of South Florida Tampa, Florida 33606 {dagger}Department of Obstetrics and Gynecology, University of Tennessee Memphis, Tennessee 38103 {ddagger}The Harlow Primate Laboratory, Department of Psychology, University of Wisconsin Madison, Wisconsin 53715 §Department of Obstetrics and Gynecology, Rush Medical College Chicago, Illinois 60521

Received June 4, 1993; accepted August 17, 1993

Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. RIER, S. E., MARTIN, D. C., BOWMAN, R. E., DMOWSKI, W. P., AND BECKER, J. L. (1993). Fundam. Appl. Toxicol. 21, 433–441.

The incidence of the reproductive disease endometriosis was determined in a colony of rhesus monkeys chronically exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) for a period of 4 years. Ten years after termination of dioxin treatment, the presence of endometriosis was documented by surgical laparoscopy and the severity of disease was assessed. The incidence of endometriosis was directly correlated with dioxin exposure and the severity of disease was dependent upon the dose administered (p < 0.001). Three of 7 animals exposed to 5 ppt dioxin (43%) and 5 of 7 animals exposed to 25 ppt dioxin (71%) had moderate to severe endometriosis. In contrast, the frequency of disease in the control group was 33%, similar to an overall prevalence of 30% in 304 rhesus monkeys housed at The Harlow Primate Center with no dioxin exposure. This 15-year study indicates that latent female reproductive abnormalities may be associated with dioxin exposure in the rhesus. Therefore, the effects of this toxin may be more diverse than previously recognized.


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