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© 1994 Oxford University Press

research-article

Air Samples from a Building with Asbestos-Containing Material: Asbestos Content and in Vitro Toxicity on Rat Pleural Mesothelial Cells

HANGYING DONG*, LAURE SAINT-ETIENNE*, ANNIE RENIER*, MARIE-ANNICK BILLON GALLAND{dagger}, PATRICK BROCHARD*,{dagger} and MARIE-CLAUDE JAURAND*,1

*Laboratory of Environmental Cellular and Molecular Pathology, Institut National de la Santé et de la Recherche Médicale (INSERM)U 139. CHU Henri Mondor.94010 Créteil Cedex, France {dagger}Laboratoire d'Etudes des Particules Inhalées 11 rue Georges Eastman, 75013 Paris, France

Received February 18, 1993; accepted September 28, 1993

Buildings equipped with asbestos-containing material may release asbestos fibers, the toxicity of which remains uncertain because of the generally low dose level. In 22 air samples collected in a building the asbestos level ranged between 0 and 0.027 f/ml. Both chrysotile and amphiboles were found. There was no association between in vitro cytotoxicity on rat pleural mesothelial cells and asbestos content, but there was a significant correlation with the total amount of particulate material. Four samples exhibited an enhancement of DNA synthesis in cells arrested in G1 with 5 mM hydroxyurea. This is more likely related to the particulate matter associated with asbestos fibers.


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