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© 1995 Oxford University Press

research-article

Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-1{alpha} Alone or Combined

SATHASIVA B. KANDASAMY*, ARUN B. THIAGARAJAN{dagger},1 and ALAN H. HARRIS*

*Behavioral Sciences Department, Armed Forces Radiobiology Research Institute Bethesda, Maryland 20889-5603 {dagger}Section Neurochemistry, National Institute on Alcohol Abuse and Alcoholism Bethesda, Maryland 20892-5145

Received February 8, 1994; accepted September 28, 1994

Exposing rats to 1–10 Gy of ionizing radiation increased plasma adrenocorticotropic hormone (ACTH) and corticoste-rone (CORT) levels. In both irradiated and nonirradiated rats, recombinant human interleukin-1{alpha} (rhIL-1{alpha} 1 hr before radiation/sham exposure) enhanced plasma ACTH and CORT levels. Indomethacin, a cyclooxygenase inhibitor, attenuated plasma ACTH and CORT levels induced by radiation. Indomethacin also attenuated ACTH and CORT levels induced by radiation and interleukin-1{alpha} alone or combined. These results suggest that prostaglandins are involved in the increase in plasma ACTH and CORT levels induced by radiation and rhIL-1{alpha} alone or combined.


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