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© 1995 Oxford University Press

research-article

An Explanation on the Limited Efficacy of Detoxication against VX Toxicity by Purified Specific Antibodies

WAN-GUO LIAO and KANG-TAI RONG1

Institute of Pharmacology and Toxicology P.O. Box 130(6), Beijing 100850, People's Republic of China

Received March 18, 1994; accepted February 28, 1995

Studies on the mechanism of detoxication against VX toxicity by purified rabbit anti-VX antibodies were carried out in mice. VX (25 µg/kg) was injected subcutaneously immediately following intravenous injection of purified anti-VX antibodies. Blood concentration of free VX declined linearly as the antibody dose increased. Free YX concentration in brain was far lower than that in blood. When the dose of purified anti-VX antibodies was 8 and 6 mg/kg, respectively, free VX concentration in brain and blood approached 0. At the same time, the cholinesterase (ChE) activity in brain increased along with increasing antibody dose, with 70% of normal control value detected when 8 mg/kg antibodies were administered. On the other hand, anti-VX antibodies were not able to protect blood ChE unless the VX dose was lower than 10 µg/kg. The studies suggest that the protective action of purified rabbit anti-VX antibodies is from VX antibodies combining with the free VX in blood and extravascular tissue to reduce the amount of VX entering into the brain.


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