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© 1996 Oxford University Press

other

Endocrine Modulation of Reproduction1

ROBERT E. CHAPIN*, JAMES T. STEVENS{dagger}, CLAUDE L. HUGHES{ddagger}, WILLIAM R. KELCE§, REX A. HESS and GEORGE P. DASTON||

*Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709 {dagger}Department of Toxicology, Crop Protection Division Ciba-Geigy, Greensboro, North Carolina {ddagger}Comparative Medicine Clinical Research Center, Department of Comparative Medicine and Obstetrics & Gynecology, The Bowman Gray School of Medicine, Wake Forest University Winston Salem, North Carolina 27109 §Reproductive Toxicology Branch, Developmental Toxicology Division, Health Effects Research Lab, U.S. EPA Research Triangle Park, North Carolina 27711 Department of Veterinary Biosciences, University of Illinois Urbana, Illinois 61801 ||The Procter and Gamble Co. Cincinnati, Ohio

Received June 9, 1995; accepted June 13, 1995

The ability of foreign compounds to affect the functioning of various endocrine systems is currently thought responsible for a wide variety of effects. The presentations in this Symposium reviewed the evidence for and against the involvement of endocrine systems in several different aspects of reproduction. The mechanism behind the ability of a triazine herbicide to cause enhanced appearance of mammary tumors in one strain of female rats is reviewed by Stevens. The data suggest that enhanced aging, not direct mammary modulation, is responsible. Dietary phytoestrogens, the mediators of their actions, their effects in various biological systems, and the relationships between phytoestrogen producers and consumers are all provocatively and succinctly reviewed by Hughes. Kelce presents the strategy used to dissect the mode and mechanisms of action of a fungicide that opened a new awareness in reproductive toxicology: the possibility of xenobiotics being antiandrogens. Finally, to heighten our understanding of the interplay among hormonal systems in vivo, Hess reviews the data that show that androgens are not the only hormones important in the development of the male reproductive system: the pituitary is shown to play a critical role at specific stages of development. The breadth of these presentations, and the implications of their findings, should make us pause and realize how much there is still to discover about the interaction between the reproductive system and anthropogenic compounds.


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