Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MILLER, R. R.
Right arrow Articles by McKENNA, M. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by MILLER, R. R.
Right arrow Articles by McKENNA, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983 Oxford University Press

research-article

Ethylene Glycol Monomethyl Ether. I. Subchronic Vapor Inhalation Study with Rats and Rabbits

R. R. MILLER, J. A. AYRES, J. T. YOUNG and M. J. McKENNA

Toxicology Research Laboratory, Health and Environmental Sciences U.S.A. Dow Chemical U.S.A. Midland, Michigan 48640

Ethylene Glycol Monomethyl Ether. I. Subchronic Vapor Inhalation Study with Rats and Rabbits. (1983). Fundam. Appl. Toxicol. 3:49-54. Male and female Sprague-Dawley rats and New Zealand White rabbits were exposed to 0,30, 100 or 300 ppm ethylene glycol monomethyl ether (EGME) vapors 6 hours per day, 5 days per week, for a total of 13 weeks. No rats died prior to scheduled sacrifice, but some rabbits in the 100 and 300 ppm exposure groups died or were sacrificed when moribund during the study. Body weights as well as thymus and testicular weights of rats and rabbits in the 300 ppm group were reduced as a result of the exposures. Hematologic changes occurred in rats and rabbits exposed to 300 ppm. Concentrations of total protein, albumin and globulins in serum of rats (but not rabbits) in the 300 ppm group were lower than for controls. Gross lesions in rats and rabbits exposed to 300 ppm EGME included decreased size of thymus in both sexes, decreased abdominal fat, and small flaccid testes in males. In addition there was decreased lymphoid tissue in some rabbits, as well as a slight-to-moderate decrease in size of testes in 4 of 5 rabbits in the 100 ppm group and in 2 of 5 rabbits exposed to 30 ppm. Treatment-related microscopic lesions included degenerative changes in germinal epithelium of testes in all male rats and rabbits in the 300 ppm group, as well as in 3 of 5 rabbits in the 100 ppm group and 1 of 5 male rabbits in the 30 ppm group. The only effects attributed to exposure to 30 ppm EGME in this study were slight microscopic changes in testes of 1 of 5 male rabbits.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.