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© 1983 Oxford University Press

research-article

Some Innovating Models in Teratogenicity: Correlating Pharmacokinetics and Teratogenic Endpoints

CAROLE A. KIMMEL* and JOHN F. YOUNG

Division of Teratogenesis Research, National Center for Toxicological Research/FDA/DHHS Jefferson, AR 72079

Correlating Pharmacokinetics and Teratogenic Endpoints. Kimmel, C.A. and Young, J.F. (1983). Fundam. Appl. Toxicol. 3: 250–255. The use of pharmacokinetics can improve the extrapolation of animal teratology data for human risk evaluation. Before one can extrapolate between species, however, the pharmacokinetic model must be predictable within the species for which it was developed. This article summarizes an approach being used for correlating pharma.


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