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© 1983 Oxford University Press

research-article

Fractional Hepatic Localization of 14CHCl3 in Mice and Rats Treated with Chlordecone or Mirex

L. ARTHUR HEWITT, WILLIAM R. HEWITT* and GABRIEL L. PLAA{dagger}

Département de Pharmacologie, Faculté de Médecine et Faculté des études Supérieures, Université de Montréal Montréal, Québec, Canada H3C 3J7

Fractional Hepatic Localization of 14CHCl3 in Mice and Rats Treated with Clordecone or Mirex. Hewitt, L.A., Hewitt, W.R., and Plaa, G.L. (1983). Fundam. Appl. Toxicol. 3:489–495. In rodents chlordecone, but not mirex, a nonketonic structural analog, significantly augments CHCl3-induced liver damage, at least in part, by increasing CHCl3 bioactivation. To determine whether the fractional distribution of CHCl3 was altered in chlordecone-pretreated animals, the irreversible binding of 14CHCl3 to various liver constituents (a measure of CHCl3 bioactivation) was examined in vivo in mice and rats. Chlordecone, but not mirex, increased both total and irreversibly bound 14CHCl3; furthermore, changes in the 14Clocalization between lipid, protein and acid-soluble fractions were noted. Thus, the results suggest that differences exist between chlordecone and mirex with respect to their capacity to increase the quantity of CHCl3-derived reactive metabolite and the eventual distribution of reactive metabolite.


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