Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by CLEMENT, J. G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by CLEMENT, J. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1983 Oxford University Press

research-article

Efficacy of Mono- and Bis-Pyridinium Oximes Versus Soman, Sarin and Tabun Poisoning in Mice*

JOHN G. CLEMENT

Biomedical Section, Defence Research Establishment Suffield Ralston, Alberta, Canada T0J 2N0

Efficacy of Mono- and Bis-Pyridinium Oximes Versus Soman, Sarin and Tabun Poisoning in Mice. Clement, J.G. (1983). Fundam. Appl. Toxicol. 3:533–535. Various oximes (PAM, toxogonin, TMB-4, HS-6, HI-6, HGG-12, HGG-42) combined with atropine were compared as antidotes of soman, sarin and tabun poisoning in non-fasted CD-1® male mice. TMB-4 was the most toxic oxime with an i.p. LD50 value of 80 mg/kg and HI-6 was the least toxic oxime with an i.p. LD50 of 588 mg/kg. Upon comparing ED50 values, HGG-42 was the most effective oxime versus soman and tabun poisoning whereas, HI-6 was the most effective oxime versus sarin poisoning. Further research needs to be done to explain the distinct differences in efficacy of the oximes versus poisoning by soman, sarin or tabun.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.