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© 1996 Oxford University Press

research-article

Diesel Exhaust Is Not a Pulmonary Carcinogen in CD-1 Mice Exposed under Conditions Carcinogenic to F344 Rats

JOE L. MAUDERLY*, DEBORAH A. BANAS{dagger}, WILLIAM C. GRIFFITH*, FLETCHER F. HAHN*, ROGENE F. HENDERSON* and ROGER O. MCCLELLAN{ddagger}

*Inhalation Toxicology Research Institute P.O. Box 5890, Albuquerque, New Mexico 87185 {dagger}Experimental Pathology Laboratories Box 474, Herndon, Virginia 22070 {ddagger}Chemical Industry Institute of Toxicology P.O. Box 12137, Research Triangle Park North Carolina 27709

Received June 7, 1995; accepted October 13, 1995

Differences among laboratory animal species in the pulmonary carcinogenicity of chronic inhalation exposure to diesel exhaust have raised several important interpretive issues. Under similar heavy exposure conditions, it is clear that diesel exhaust is a pulmonary carcinogen in rats, but not in Syrian hamsters. Previous reports give conflicting views of the response of mice, which is presently considered equivocal. This report describes carcinogenicity results from a bioassay of CD-1 mice conducted in parallel with a previously reported bioassay of F344 rats (Mauderly et al. (1987) Fundam. Appl. Toxicol. 9, 208–221). Exposure to whole diesel exhaust 7 hr/day, 5 days/week for 24 months at soot concen trations of 0.35, 3.5, or 7.1 mg/m3 caused accumulations of soot in mouse lungs similar to those in lungs of rats and, like the results from rats, did not significantly affect survival or body weight. In contrast to the dose-related neoplastic response of rats, however, the exposures of mice did not increase the incidence of lung neoplasms. This finding is consistent with other data showing that mice, as well as Syrian hamsters, differ from rats in their lung neoplastic and nonneoplastic responses to heavy, chronic inhalation exposure to diesel exhaust soot and several other particles. Although rodents serve as useful indicators of potential human carcinogenic hazards, it is not yet clear which, if any, rodent species have lung neoplastic responses that are useful for quantitative predictions of human lung cancer risk from chronic inhalation of poorly soluble, respirable particles.


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