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© 1996 Oxford University Press

research-article

Increased Immune and Inflammatory Responses to Dust Mite Antigen in Rats Exposed to 5 ppm NO21

MATTHEW I. GILMOUR*, PATRICIA PARK{dagger} and MARYJANE K. SELGRADE{dagger}

*Center for Environmental Medicine, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514 {dagger}Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park North Carolina 27711

Received February 13, 1995; accepted November 21, 1995

Immune hypersensitivity to house dust mite antigen (HDM) is a frequent cause of respiratory allergy. The objective of this study was to determine whether exposure to NO2, a common indoor air pollutant, modulates immune responses to HDM and influences immune-mediated lung disease. Brown Norway rats were immunized ip with 100 µg semipurified antigen and Bordetella pertussis adjuvant and challenged 2 weeks later with an intratracheal injection of 50 µg of a crude antigen preparation. Exposure to 5 ppm NO2 for 3 hr after both immunization and challenge procedures resulted in significantly higher levels of antigen-specific serum IgE, local IgA, IgG, and IgE antibody than air controls, and increased numbers of inflammatory cells in the lungs. Lymphocyte responsiveness to antigen in the spleen and MLN was also significantly higher in NO2-exposed animals. These data show that exposure to a common air pollutant can upregulate specific immune responses and subsequent immune-mediated pulmonary inflammation.


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