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© 1996 Oxford University Press

research-article

Chelation in Metal Intoxication XXXVIII: Effect of Structurally Different Chelating Agents in Treatment of Nickel Intoxication in Rat

S. K. TANDON1, S. SINGH, V. K. JAIN and S. PRASAD

Chemical Toxicology, Industrial Toxicology Research Centre Lucknow—226 001, India

Received June 12, 1995; accepted December 15, 1995

Some structurally different chelating agents viz. {alpha}-mercapto-ß-(2-furyl) acrylic acid (MFA), {alpha}-mercapto-ß-(2-thienyl) acrylic acid (MTA), meso 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercap-topropane-1-sulfonate (DMPS), diethyl dithiocarbamate (DE-DTC), and N-benzyl-D-glucamine dithiocarbamate (NBG-DTC) were evaluated for their efficacy to mobilize nickel and reverse some nickel-induced biochemical alterations in experimental nickel intoxication. MFA, DMSA, and NBG-DTC appear more effective than their corresponding homologs, MTA, DMPS and DE-DTC, respectively, in enhancing urinary and fecal excretion of nickel and lowering tissue burden of nickel in nickel preexposed rats. These, particularly NBG-DTC, appear promising in the treatment of nickel (II) poisoning. However, there seems no definite relationship between the structure of the chelating agents examined and their ability to counteract the effects of nickel.


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