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© 1996 Oxford University Press

research-article

Protection of Organophosphate-Inactivated Esterases with Phosphotriesterase

KAI TUOVINEN*,1, EILA KALISTE-KORHONEN{dagger}, FRANK M. RAUSHEL{ddagger} and OSMO HANNINEN*

*Department of Physiology University of Kuopio, P.O. Box 1627. FlN-70211 Kuopio. Finland {dagger}National Laboratory Animal Center University of Kuopio, P.O. Box 1627. FlN-70211 Kuopio. Finland {ddagger}Department of Chemistry, Texas A & M University College Station, Texas 77843

Received August 17, 1995; accepted January 29, 1996

The protective effect of phosphotriesterase (PTE) on cholinesterase (ChE) and carboxylesterase (CaE) activities was studied in mice. The PTE pretreatment (120 U/g body wt, 9.6 µg/g body wt) given iv 10 min before diisopropyl fluorophosphate, sarin, or so-man variably prevented ChE inhibition in erythrocytes and plasma and CaE in plasma. PTE also protected the brain and lung ChEs against inactivation by organophosphates (OPs). The recovery of the enzymes was dependent on the OP used. Postexposure therapy with PTE, given 1.5 hr after paraoxon, also prevented ChE inhibition in erythrocytes, brain, and lung 24 hr after exposure. The distribution studies with [125I]PTE showed that PTE does not markedly gain access into the central nervous system.


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