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© 1996 Oxford University Press

research-article

Chronic Dietary Toxicity/Oncogenicity Studies on 2,4-Dichlorophenoxyacetic Acid in Rodents1

JEFFREY M. CHARLES*, DENISE M. BOND{dagger}, TONI K. JEFFRIES{dagger}, BARRY L. YANO{dagger}, WILLIAM T. STOTT{dagger}, KEITH A. JOHNSON{dagger}, HELEN C. CUNNY{ddagger}, RONALD D. WILSON§ and JAMES S. BUS{ddagger},2

*Charles, Conn, & van Gemert, LLC Durham, North Carolina 27705 {dagger}Dow Chemical Company Midland, Michigan 43674-0001 {ddagger}Rhone-Poulenc Ag Company Research Triangle Park, North Carolina 27705 §John Wise & Associates, Ltd. Liberry, Missouri 64068

Received May 15, 1996; accepted May 18, 1996

Forms of 2,4-dichlorophenoxyacetic acid (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. Doses in the 2-year chronic/oncogenicity rat study were 0, 5, 75, and 150 mg/kg/day. The chronic toxicity paralleled subchronic findings, and a NOEL of 5 mg/kg/day was established. A slight increase in astrocytomas observed (in males only) at 45 mg/kg/day in a previously conducted chronic rat study was not confirmed in the present study at the high dose of 150 mg/kg/day. Doses in the 2-year mouse oncogenicity studies were 0, 5, 150, and 300 mg/kg/day for females and 0, 5, 62.5, and 125 mg/kg/day for males. No oncogenic effect was noted in the study. In summary, the findings of these studies indicate low chronic toxicity of 2,4-D and the lack of oncogenic response to 2,4-D following chronic dietary exposure of 2,4-D in the rat and mouse.


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