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© 1996 Oxford University Press

research-article

Measurement of the Flux of Lead from Bone to Blood in a Nonhuman Primate (Macaca fascicularis) by Sequential Administration of Stable Lead Isotopes

M. J. INSKIP*,1, C. A. FRANKLIN{dagger}, C. L. BACCANALE*, W. I. MANTON{ddagger}, E. J. O'FLAHERTY§, C. M. H. EDWARDS*,¶, J. B. BLENKINSOP and E. B. EDWARDS*

*Health Protection Branch Health Canada, Ottawa, Ontario, Canada {dagger}Pest Management Regulatory Agency Health Canada, Ottawa, Ontario, Canada {ddagger}Mass Spectrometry Laboratory, University of Texas at Dallas Richardson, Texas §Department of Environmental Health, University of Cincinnati College of Medicine Cincinnati, Ohio Department of Earth Sciences, Carleton University Ottawa, Ontario, Canada

Received November 22, 1995; accepted April 26, 1996

To better understand the kinetics of the transfer of lead from bone to blood, we have developed and tested a method in which sequential doses of lead, each enriched with a different stable isotope, were administered in a nonhuman primate Macaca fascicularis whose skeleton had been previously labeled with lead of known isotopic composition. Lead isotopic ratios of blood and bone samples, analyzed by thermal ionization mass spectrometry (TIMS), were unmixed by isotope dilution techniques. The first label administered allows the contribution from historical bone stores to be measured. Subsequent labels allow measurement of both the historical bone stores and the previous labels that have become recently incorporated into bone. The method may be extended to studies of bone lead mobilization in pregnancy, lactation, menopause, or in disease states such as postmenopausal osteoporosis.


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