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© 1997 Oxford University Press

research-article

Inhibition of 3,3',4,4',5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2',4,4',5,5'-Hexachlorobiphenyl

FENG ZHAO*, KITTANE MAYURA*, NATHAN KOCUREK*, JOHN F. EDWARDS{dagger}, LEON F. KUBENA{ddagger}, STEPHEN H. SAFE§ and TIMOTHY D. PHILLIPS*,1

*Department of Veterinary Anatomy and Public Health Texas 77843-4458 {dagger}Department of Veterinary Pathobiology, Texas A&M University, College Station Texas 77843-4458 {ddagger}U.S.D.A. Agricultural Research Service, College Station Texas 77843 §Department of Veterinary Physiology and Pharmacology Texas 77843-4458

Received November 9, 1995; accepted September 10, 1996

3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 µg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 µ/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.


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