Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by RE, T. A.
Right arrow Articles by BURNETT, C. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by RE, T. A.
Right arrow Articles by BURNETT, C. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1984 Oxford University Press

research-article

Results of Teratogenicity Testing of m-Aminophenol in Sprague-Dawley Rats

THOMAS A. RE*, RICHARD F. LOEHR*, STEPHEN C. RODRIGUEZ*, DEAN E. RODWELL{dagger} and CLYDE M. BURNETT*

*Clairol Research Laboratories 2 Blachley Road, Stamford, Connecticut 06902 {dagger}WIL Research Laboratories, Inc 3154 Exon Avenue, Cincinnati, Ohio 45241

Results of Teratogenicity Testing of m-Aminophenol in Sprague-Dawley Rats. RE, T. A., LOEHR, R. F., RODRIGUEZ, S. C., RODWELL, D. E., AND BURNETT, C. M. (1984). Fundam. Appl. Toxicol. 4, 98–104. meta-Aminophenol (m-AP) was administered in the diet to female Sprague-Dawley rats for a period of at least 90 days at levels of 0.1, 0.25, and 1.0%. In the 0.25% group a significant reduction in body weight was noted, in comparison with control values, and in the 1.0% group a significant reduction in both body weight and food consumption was noted. Ten of the rats in each group were necropsied. Deposition of iron positive pigment in the spleen, liver, and kidney combined with decreased red blood cell count and hemoglobin and increased mean corpuscular volume indicated a hemolytic effect. There were also morphologic changes in the thyroid which were consistent with hyperactivity. The remaining 25 rats in each group were removed from m-AP treatment and immediately mated to untreated males of the same strain. After the mating period the dams again were given m-AP for the duration of gestation. All dams were killed on Day 20 of gestation; one-third of the fetuses were examined for visceral malformations and two-thirds for skeletal malformations and variations. An additional significant reduction in body weight gain was noted during gestation in the 1.0% group as compared to the control group. There were no other adverse dose-related findings demonstrated in the reproduction performance of the dams or in the survival or development of their offspring. Therefore, although maternal toxicity was demonstrated at the highest dose level, there was no evidence of teratogenic or embryofetal toxicity at any dose level tested.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.