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© 1984 Oxford University Press

research-article

Diesel Exhaust Exposure System for Animal Studies

BRIAN V. MOKLER1, FRANK A. ARCHIBEQUE2, RONALD L. BEETHE3, CHRISTOPHER P. J. KELLY4, JOHN A. LOPEZ, JOE L. MAUDERLY and DAMON L. STAFFORD5

Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute P.O. Box 5890. Albuquerque, New Mexico 87185

Diesel Exhaust Exposure System for Animal Studies. MOKLER, B. V., ARCHIBEQUE, F. A., BEETHE, R. L., KELLY, C. P. J., LOPEZ, J. A., MAUDERLY, J. L., AND STAFFORD, D. L. (1984). Fundam. Appl. Toxicol. 4, 270–277. Planned exposures of rodents to diesel exhaust required development of an exhaust generation and delivery system flexible enough to accommodate varied experimental designs. The features of the exposure system built to meet these needs are summarized. Essential aspects including both the exhaust dilution and delivery system and the computer monitoring and control functions are described. During the first 29 weeks of a study with target particle concentrations of 350, 3500, and 7000 µg/m3, the achieved values were 310, 3360, and 6830 µg/m3 with coefficients of variation of 23, 10, and 9%, respectively. The system has now operated reliably for more than 24 months.


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