Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HAYES, A. W.
Right arrow Articles by KOPCHIK, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by HAYES, A. W.
Right arrow Articles by KOPCHIK, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1984 Oxford University Press

research-article

A Toxicology Program for Evaluating the Safety of a Chemical Warfare Decontaminant

A. W. HAYES, P. K CHAN, G. P. O'HARA, J. M. SMITH and R. KOPCHIK

Toxicology Department, Rohm and Haas Company Spring House, Pennsylvania 19477

A Toxicology Program for Evaluating the Safety of a Chemical Warfare Decontaminant. HAYES, A. W., CHAN, P. K., O'HARA, G. P., SMITH, J. M., AND KOPCHIK, R. (1984). Fundam. Appl. Toxicol. 4, S145–S149. An ideal topical decontaminant for chemical warfare agents should be highly efficacious, easy to use, and have low toxicity. For toxicity assessment, a stepwise approach linking type of toxicity study to stage of decontaminant development is both efficient and economical. In the initial exploratory phase, range-finding acute toxicity studies using a few animals will suffice to screen out highly toxic decontaminants. More definitive acute toxicity studies and a short term mutagenic test are sufficient during the live agent efficacy testing phase. When an efficacious decontaminant is found and is ready to be formulated into a product, a more extensive toxicologic program including a 2-week dermal toxicity study, a skin sensitization study, and an inhalation study (for aerosol or powder formulations) should be implemented before clinical trials.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.