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© 1984 Oxford University Press

discussion

Determining "Safe" Levels of Exposure: Safety Factors or Mathematical Models?

DANIEL KREWSKI*, CHARLES BROWN{dagger} and DUNCAN MURDOCH*

*Health Protection Branch, Heath & Welfare Canada Ottawa, Ontario KIA 0L2, Canada {dagger}Biometry Branch, National Cancer Institute Washington, D.C. 20205

Determining "Safe" Levels of Exposure: Safety Factors or Mathematical Models? KREWSKI, D., BROWN, C, and MURDOCH, D. (1984). Fundam. Appl Toxicol A, S383–S394. The object of regulatory toxicology is to determine "safe" levels of human exposure to toxicants present in the environment The traditional safety factor approach is compared to more recent mathematical modeling techniques, outlining the underlying assumptions and statistical properties of each procedure. Several linear extrapolation procedures are examined in detail using computer simulation, along with the impact of nonlinear kinetics on the extrapolation process.


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