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© 1984 Oxford University Press

research-article

Toxic Effects of Cu Implants on Liver1

JOHN C. KELLER2, and EDWARD J. KAMINSKI

Departments of Biological Materials and Pathology, Northwestern University Chicago, Illinois 60611

Toxic Effects of Cu Implants on liver. KELLER, J. C, AND KAMINSKI E. J. (1984). Fundam. Appl. Toxicol. 4, 778–783. In an effort to identify possible systemic effects due to dissolution of Cu from the experimental use of dental amalgam specimens of pure Cu and several dental amalgams containing various concentrations of Cu were implanted into the peritoneal cavity of rats for 4 weeks. Concentrations of Cu in the liver varied from 33.3 to 156.2 µCu/dry g of liver tissue after implantation of the Cu-containing amalgams. Histopathological changes in the liver confirmed the presence of Cu within the tysosomes of hepatocytes. The histopathological and chemical changes in the liver after implantation indicated the need for subsequent investigations of long-term systemic toxicity to the use of Cu-containing implants


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